The Italian Regulatory Guidelines for the implementation of Patient Blood Management

Comment in Towards the implementation of patient blood management across Europe. [Blood Transfus. 2017

The practical management of non traumatic cerebral haemorrhage in the acute phase: a call to action

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Recommendations for the implementation of a Patient Blood Management programme. Application to elective major orthopaedic surgery in adults

Methodology for producing the recommendations for the implementation of a Patient Bloo

The intracerebral haemorrhage associated to oral anticoagulant therapy: the practical management of urgent reversal therapy

Intracerebral haemorrhage (ICH) represents the most feared complication of therapy with vitamin K antagonists (VKA), so-called oral anticoagulant therapy (OAT). This is a real emergency in clinical practice, being burdened by high mortality, morbidity and residual functional disability. In recent years, there have been widespread indications for the correct management of VKA associated ICH. The urgent OAT reversal represents the cornerstone of VKA associated ICH therapy. The knowledge of these guidelines is of fundamental importance in clinical practice. The urgent OAT reversal could stop the hematoma enlargement which is considered one of the main risk factor of poor outcome in this clinical setting. The aim of urgent OAT reversal is bringing the INR (International Normalized Ratio) to values ≤ 1.4. It is possible by using prothrombin complex concentrate (PCC), fresh frozen plasma (FFP), recombinant activated factor VII (raFVII) together with vitamin K1 intravenous infusion. In this article the Authors review the practical management of urgent OAT reversal in patients suffering for VKA related ICH

Prolonged higher dose methylprednisolone vs. conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS)

Dysregulated systemic inflammation is the primary driver of mortality in severe COVID-19 pneumonia. Current guidelines favor a 7-10-day course of any glucocorticoid equivalent to dexamethasone 6 mg·day-1. A comparative RCT with a higher dose and a longer duration of intervention was lacking